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Mitochondria are also the main source of reactive oxygen species (ROS) and reactive nitrogen species (RNS)

Nevertheless, due to the compensative mechanisms of the basal ganglia, thalamic nucleus, and the cerebellum, the clinical symptoms of motor deficits do not appear until 50%70% of the dopaminergic neurons in substantial nigra are impaired and the dopamine levels in the striatum are depleted by approximately 80% (George et al., 2009

Peters JM, Park Y, Gonzalez FJ, et al

doi: 10.1152/physrev.00040.2012

found that significant enrichment of Th2 and Th17 lymphocyte subsets identified within bronchoalveolar lavage samples obtained from individuals diagnosed with asthma could trigger IL-4 overproduction and subsequently augment the capability of inducing glucocorticoid resistance in vitro [131]