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Through a distinct mechanism, choline uptake and PC synthesis regulate IL-1 production mediated by NLRP3 inflammasome activation (69) ( Figure 3 )

doi:10.3389/fphys.2021.606931 Cappola AR, Desai AS, Medici M, et al

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13 Because acyl coenzyme A formed in the endoplasmic reticulum or outer mitochondrial membrane cannot penetrate the inner mitochondrial membrane to the site of fatty acid -oxidation, the acyl group must be transferred from coenzyme A to carnitine