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These include parathyroid hormone (PTH), IGF-1, serotonin (5-HT), melatonin, peptide YY (PYY), and the incretin hormones glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and glucagon-like peptide 2 (GLP-2) (78, 79)

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In the CT-like conformation, the bypass motif becomes unstructured, and residues (S21-P28) are not well resolved, suggesting this flexible segment is exposed to the solvent environment