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Additionally, B-factors were examined to shed light on atomic mobility within the structure, offering a comprehensive understanding of its stability and dynamic behaviour, as illustrated in Figure 10

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[28]Edwards BA, Kushner DS, et al

Preclinical studies were assessed for reproducibility of models, dosing regimens, and outcome measures, while clinical studies were examined for study design (randomized, controlled, blinded), sample size, and risk of bias

We also added glutathione reductase Gor (1 M) and its co-substrate NADPH+H + (250 M), to ensure the retention of the reduced state of the exogenous glutathione (see Figure 6D for a schematic overview)