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Age: Older patients may have slower response times Health status: Presence of comorbidities can affect treatment outcomes Lifestyle factors: Diet, exercise, and smoking status can influence efficacy Healthcare providers can tailor stem cell patch therapy better by understanding these factors

Epidermal Growth factors allow the production of Elastin and Collagen Fibers, which promotes skin healing and leads to an anti-aging effect

Pathological -synuclein upregulation induces ferroptosis by reducing NRF2 protein levels and impairing antioxidant defenses (56)

Through EMT, epithelial cells lose cell polarity, connections to the basement membrane and other epithelial phenotypes, and gain mesenchymal phenotypes such as increased migratory and invasive abilities, anti-apoptotic features and the capacity to degrade the extracellular matrix (79)

doi: 10.1038/nature17625 102 MuratS.AlpG.AlataliC.UzunM