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Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)

Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimers disease treatment

In women, the optimal ferritin level is often between 80 and 100 g/l

Central to its mechanism is the modulation of the nitric oxide (NO) system, where it can either promote or inhibit NO synthesis depending on tissue context

Between 10-year-old girls buying retinol serums and the jump in outlandish cosmetic procedures, our youth-obsessed culture will do almost anything to hold onto younger-looking skin for as long as possible