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That signal travels to the pituitary, where it binds to GHRH receptors on somatotroph cells

So I think anybody can get Alzheimer's disease with any genotype if there's enough insulin resistance, if there's basically enough difficulty in getting glucose through pyruvate dehydrogenase and into the Krebs cycle

Zura R, Della Rocca GJ, Mehta S, Harrison A, Brodie C, Jones J, et al

He L, Long J, Zhou X, Liu Y, Li T, Wu X (2020) Serine is required for the maintenance of redox balance and proliferation in the intestine under oxidative stress

Normally, ROS are key signaling molecules in plant cell cycle regulation and programmed death (Livanos et al., 2012