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The DM-associated complications, such as high glucose levels, can stimulate ROS generation through PKC and NADPH-dependent pathways in various cells, such as aortic endothelial cells, smooth muscle cells, and renal mesangial cells (N

This tolerance-building process is analogous to allergy immunotherapy, where repeated exposure to an allergen gradually desensitizes the immune system

transporters, channels, receptors, or adhesion proteins

Hoyos V, Savoldo B, Quintarelli C, Mahendravada A, Zhang M, Vera J, et al

Although it is not universally accepted (43, 56), several authors argue that interventions that increase cGMP signaling (e.g., NO donors, cGMP analogs, etc.) reduce skeletal muscle force production (1, 46, 221, 250, 251, 327)