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Selenium deficiency may exacerbate the goiter by impairing the thyroids ability to function correctly, even in iodine-sufficient areas [91]

However, around 85% of PA patients have parietal cell antibodies, which means they are a sensitive marker for the disease

& Clment, K.) 165180 (Springer, 2021)

There also appear to be key differences between the effects of individual macronutrients, where carbohydrates lead to equal stimulation of the HPA axis and 11HSD1, and where fat and protein led to greater stimulation of the HPA axis compared to 11HSD1

The first is glutathione peroxidase (GPx) an enzyme family that the literature describes as a selenium-containing catalyst