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When stratified by administration route, the mean percentage changes were: Intramuscular (IM): 307% Oral: 285% Sublingual: 199% IM administration showed the highest average B12 increase, although oral and sublingual routes also yielded substantial improvements, supporting their use as effective and less invasive alternatives

Image Credit: bitt24 / Shutterstock How is B12 absorbed

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Evidence suggests that it can reverse HFD-induced obesity in mice (Neelakantan et al., 2018

The dose needed depends on how bad the deficiency is, your age, and your health