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Mediators Inflamm 2014;2014:837107

Nobody can, until someone actually runs the trial

Human pharmacokinetics are extrapolated rather than directly measured (dihexa has not completed clinical trials), but allometric scaling suggests a similar range of one to three hours

Compared to patients with creatinine clearance greater than 80 mL/min (N = 37), patients with creatinine clearance = 50-80 mL/min (N = 15) showed an average increase in plasma AUC of 15%, whereas patients with creatinine clearance = 30-50 mL/min (N = 11) showed an average increase in plasma AUC of 43%