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Importantly, severe immune-mediated toxicities characteristic for ICI have not been documented for DCV, which makes these therapies particularly attractive for the adjuvant setting and for combination strategies in patients who have already received multiple lines of systemic treatment and allows a prolonged vaccination schedule [33, 37, 40]

Tet3, the most highly expressed TET in the brain, is activity-dependent in primary cortical neurons [53]

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Briefly, plasmid pool was used to generate a lentiviral library, which was transfected into HEK-293T cells and used to generate viral supernatant as described above