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An important ROS regulator in cancer cells is the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2), whose activity is modulated by Kelch-like ECH-associated protein 1 (KEAP1), a ubiquitin ligase that mediates the degradation of NRF2 (see also above)

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However, the native hormone is unstable and prone to aggregation, limiting its therapeutic use

CrossRef Brown Fat and Nutrition: Implications for Nutritional Interventions Lloyd Noriega, Cheng-Ying Yang, Chih-Hao Wang Nutrients.2023