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(etc) [DOI] [PubMed] [Google Scholar] 65.Komohara Y., Fujiwara Y

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Though unable to provide atomic-level detail offered by X-ray crystallography or NMR, these methods were the first to reveal that many functional proteins exist as a dynamic ensemble of conformations rather than a single fixed structure

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When iron levels are excessively high, the RANKL/OPG ratio increases, leading to the promotion of osteoclast maturation and bone resorption through TFR1-mediated iron uptake ( Figure 2 )