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From a mechanistic perspective, herbal antidepressants frequently modulate monoaminergic systems by either inhibiting MAO-A/B or augmenting the availability of serotonin, norepinephrine, and dopamine

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Specifically, the activity of the SLC7A11, SLC3A2, and GYS1 genes increases, whereas the activity of the OXSM, NUBPL, NDUFA11, NCKAP1, and LRPPRC genes decreases (Zhu et al., 2023) (Table 1)

doi: 10.1016/j.jneumeth.2025.110542, 8 DetcheverryF.SenthilS.NarayananS.BadhwarA