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This reaction weakens the binding between Keap1 and NRF2, allowing NRF2 to escape the negative regulation of Keap1 and avoiding ubiquitination and degradation

Study 2: The efficacy and safety of Reclast in the treatment of patients with osteoporosis who suffered a recent low-trauma hip fracture was demonstrated in Study 2, a randomized, double-blind, placebo-controlled, multinational endpoint study of 2127 men and women aged 50 to 95 years (mean age of 74.5)