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LCN2, an acute phase protein secreted by activated astrocytes or neutrophils, has been shown to promote neuronal ferroptosis via downregulation of SLC7A11 in various CNS disease models, including epilepsy and diabetes-associated ischemic stroke (Zhou Z

We also reviewed the available literature on HCQ-induced cutaneous hyperpigmentation and bulls-eye macular lesions and described the clinical features of HCQ-induced cutaneous hyperpigmentation and bulls-eye macular lesions

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Another possibility is that because this study was performed at a dementia clinic, the doctor and health care providers provided other forms of care to stimulate brain function, including better daily living, such as a regular lifestyle, regular meals, reading newspapers and participating in social activities, which may have influenced the improvement in the MMSE score