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doi: 10.1515/cclm-2015-1255

This interaction triggers a series of proteolytic cleavages, beginning with a furin-like protease cleavage (S1) in the Golgi, followed by additional cleavages by ADAM metalloproteases and -secretase, releasing the Notch intracellular domain (NICD)

Thus, clinical studies with selective MPO inhibitors are needed to determine if this will be a meaningful therapeutic approach to the treatment of atherosclerosis in humans