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An investigational drug, givosiran, is an RNAi therapeutic targeting aminolevulinic acid synthase 1 and is showing promise in the management of variegate porphyria.

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Free Radic Res 31:171179 Rocamonde B, Paradells S, Barcia JM, Barcia C, Garcia Verdugo JM, Miranda M, Romero Gomez FJ, Soria JM (2012) Neuroprotection of lipoic acid treatment promotes angiogenesis and reduces the glial scar formation after brain injury