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When NNMT is overactive, it depletes NAD+ stores and slows metabolic rate in fat cells

However, the mechanisms underlying these changes remain not fully understood, and cellular senescence does not always align with chronological age

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[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Branco A.F., Ferreira A., Simes R.F., Magalhes-Novais S., Zehowski C., Cope E., Silva A.M., Pereira D., Sardo V.A., Cunha-Oliveira T