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As in chow-fed mice, hepatic GSH levels were significantly decreased by approximately 90% following Chac1 overexpression (Figure 2A)

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These results demonstrate an efficient scale-up from 3 L to 250 L microcarrier bioreactors and from 20 mL to 1.5 L GSH chromatography columns and demonstrate the significant increase in productivity in GSH elution from 34C harvests