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Treating RPE cells with the iron chelator deferoxamine (DFO) can lead to a reduction in intracellular iron ions (154), an increase in genes related to iron transport, a significant elevation in the level of hypoxia-inducible factor HIF2, and impairment of mitochondrial function, indicating that the RPE is the main target tissue for DFO toxicity, resulting in atrophy and degeneration of the RPE and posing a risk of retinal detachment

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Criscuolo D, Avolio R, Parri M, Romano S, Chiarugi P, Matassa DS, et al

With 46% of adults in the UK reported to consume these vitamins as part of a regular multivitamin tablet, should we be concerned

Therefore, a dose of 100 g/mL was selected as the maximum dose to evaluate the effects of CME on LPS-induced inflammatory cytokine production in IPEC-J2 cells