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10.1016/j.bpj.2009.09.025 16 CaiM.ZhaoW.ShangX.JiangJ.JiH.TangZ.et al (2012)

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[120] Aronson WJ, Kobayashi N, Barnard RJ, et al

[52] Inheritance and spontaneous mutation [edit] The mutant gene is transmitted with an autosomal dominant pattern of inheritance, but up to 50% of NF-1 cases arise due to spontaneous mutation

Indeed, GSH works primarily by providing the reducing equivalents for antioxidant enzymes, including glutathione peroxidases [136] and ascorbate peroxidases [137] (Fig