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Moreover, pachymic acid inhibits hexokinase II and promotes the detachment of hexokinase II from mitochondria, thereby inhibiting glycolysis and initiating the mitochondrial apoptotic pathway [191]

In addition, small-molecule antioxidants such as vitamin C, vitamin E, coenzyme Q10, and GSH participate in maintaining cellular redox balance by scavenging free radicals and interrupting chain reactions [20]

Available from: Kim H-S, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, et al

[10] Native amylin is chemically unstable and short-lived, which makes it impractical as a once-weekly drug

This suggests that citrullines vasodilatory effects may be more readily unmasked during cardiovascular challenge, particularly in individuals with pre-existing vascular impairment