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The rate limiting amino acid in de novo synthesis of GSH in metabolic disease appears to be glycine

Consistently, in the GLS-deficient mouse tumor model, the increased concentration of glutamine in the TME due to restricted glutamine utilization by tumor cells leads to elevated levels of glutamine available to tumor-infiltrating T lymphocytes, thereby enhancing its anti-tumor activity [17]

Comparative quantitative lipidomic analyses of patient-matched initial versus recurrent GBM (rGBM) reveal decreased levels of ceramides, glycerolipids, sphingolipids, and triacylglycerols, alongside increased levels of glycerophosphoglycerols

Exploration 2 , 20210217 (2022)

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