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Alongside its effects on GLP-1, it also mimics the actions of another hormone called GIP (gastric inhibitory polypeptide) that reduces blood sugar levels

Calvello R, Aresta A, Trapani A, Zambonin C, Cianciulli A, Salvatore R

First-generation sulfonylureas are associated with a greater risk of adverse effects, including hypoglycemia, weight gain, and fluid retention, making second-generation drugs the recommended choice in clinical practice (126, 127)