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98,99 This review highlights that although IMF has affected the initiation and maintenance of MOUD, many core principles of OWS treatment remain the same

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The primary molecular actions relevant to skin are: modulation of TGF- signaling (upregulating TGF-1 for collagen I/III synthesis while suppressing TGF-2 to prevent scarring), decorin upregulation for orderly collagen fibril assembly, MMP suppression paired with TIMP upregulation to preserve ECM integrity, and copper-dependent lysyl oxidase activation for collagen crosslinking

10.1016/j.jmb.2005.12.030 J