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PPAR has also been found to exert anti-inflammatory effects and potential protective effects in animal models of neurological, cardiovascular, and psychiatric disorders

Some of these applications are briefly discussed below

Elevated tumor expression of the core autophagy gene ATG16L1 is associated with suboptimal clinical response to anti-PD-L1 treatment in KRAS-mutant tumors in the IMblaze370 (NCT02788279) phase III clinical study of atezolizumab for advanced metastatic MSS-CRC

2021ZKMS044, 2021ZKQN022, 2021ZKMS041]

All three running trials were completed between 0600 and 0900 to avoid circadian effects on performance (Table 1