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Human and/or mouse paraffin sections of 5 m were stained with Luxol fast blue (Solvent Blue 38, practical grade, Sigma Genosys) followed by Periodic acid Schiff (PAS) staining (Sigma) for assessment of demyelination or immunohistochemically stained with antibodies against amyloid precursor protein (clone 22C11

In clinical trials, other serious infections observed in patients treated with infliximab included arthritis bacterial, pneumonia, and urinary tract infection

Some individuals may experience improvement after the first treatment, but optimal results are typically seen after two or three treatment sessions

Although the number of available cases is small and some data are incomplete, our findings highlight the potentially high-risk role of fluoroquinolones in DILI accompanied by SJS/TEN and provide practical clues for clinical management