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Summary and Conclusion Melanin hyperpigmented disorders affect a large population in the world and lead to negative impacts on quality of life

The cumulative impact of impaired HPA regulation combined with compromised glucocorticoid and insulin receptor activity, aggravated by inflammatory cytokines, might explain the high rate of metabolic syndrome, diabetes, dyslipidemia, and osteoporosis in the bipolar population (88, 204)

Collectively, these data highlight IMPDH as a promising antifungal target, warranting further mechanistic and preclinical evaluation

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doi:10.1016/s0300-483x(00)00210-9 Cao AH, Wang J, Gao HQ, Zhang P, Qiu J