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Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer

RasmussenLJHMoffittTEArseneaultLDaneseAEugen-OlsenJFisherHLet al

The response rates were higher for cyclosporine A and methotrexate in second-line treatment than in first-line treatment (57.3% vs 68.8% and 29.1% vs 62.7%, respectively) whereas the higher response rates for cyclophosphamide was in first-line treatment (68.2% vs 57.4%)