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The combination of PBD and an antibody against ApoD demonstrated a senolytic readout by eliminating senescent fibroblasts without any effect on young cells

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Some biological activity remains, but titrating dose upward to compensate introduces cost and potential side effects without addressing the root problem

The prevalence and incidence of PD vary worldwide influenced by several factors such as age, gender, ethnicity, genetic susceptibilities, and environmental exposures

doi: 10.1016/s0022-3956(01)00013-9 Summary Keywords stress, healthcare, oxidative stress, acetylcholine, apoptosis, corticosterone, brain damage Citation Pujo JM, Fitriani DY, Ben Saad H, Ghariani M, Dghim A, Mellouli M, Burin A, Mutricy R, Houcke S, Roujansky A, Mansyur M, Nkontcho F, de Toffol B, Ben Amara I and Kallel H (2023) The effects of prolonged stress exposure on the brain of rats and insights to understand the impact of work-related stress on caregivers