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(1) Stimulate chondrocytes to synthesize Col-II and proteoglycans, while inhibiting the activities of MMP-13 and ADAMTS-5, and reducing matrix degradation

doi: 10.1023/A:1024513815374 29 BayarYavuzSAkkoS

This hypercatabolism is evident by our data demonstrating depletion of amino acids and upregulation of the urea cycle as judged by elevated levels of urea cycle metabolites such as citrulline

These findings underscore the importance of NADPH in dealing with oxidative stress especially at times when most or all of the rods have degenerated, thereby exacerbating photo-oxidation due to increase of inflow of oxygen