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Precise clinical decision-making remains challenging despite recent advances informed by data from multisite observational studies including TRACK-TBI [15,16,17], CENTER-TBI [18, 19] and the CREACTIVE project [20] to name a few

R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1

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J Cell Mol Med (2020) 24:1223445

In preclinical models, apigenin restores insulin sensitivity and ovarian function by inhibiting PI3K/Akt and downstream mTOR activation, thereby reducing excessive follicular growth and anovulation ( 9 Toxicological and safety data Experimental research indicates that apigenin is neither mutagenic nor genotoxic and is widely regarded as safe, given its broad occurrence in dietary sources such as parsley, chamomile, and celery (78)