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In a mouse model of breast cancer with TNBC cells treated with a TDO2 inhibitor, there was a significant reduction in the number of metastatic lung nodules, indicating that TDO2 enhances the metastatic capacity of TNBC cells (DAmato et al., 2015)

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Biochem J 188(2):549552 Wang X, Liu R, Zhang W, Zhang X, Liao N, Wang Z, Li W, Qin X, Hai C (2013) Oleanolic acid improves hepatic insulin resistance via antioxidant, hypolipidemic and anti-inflammatory effects