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[11] [12] There is a potential risk of pancreatitis

While adverse effects are rare, users should remain aware of potential issues and understand the limitations of current research

D88N (which breaks a salt-bridge bond with R94) and D97N (which breaks another salt bridge with R73) mutations had no effect on Lgt activity, suggesting that although these salt bridges might contribute to the structural stability of the minor TM domain, individually they are of no functional significance