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Positive results from a clinical trial involving Japanese men revealed a notable reduction in prostate cancer incidence following the oral administration of 60 mg/day isoflavones (Miyanaga et al

doi: 10.1038/nature16451 235 KroesenVMGroschelMIMartinsonNZumlaAMaeurerMvan der WerfTSet al

Handling & Storage: Store in a controlled, low-temperature environment Avoid repeated exposure to heat, moisture, and direct light Handle using appropriate laboratory safety procedures Compliance & Safety Disclaimer: This product is supplied in accordance with industry-standard research material practices

Immune cell exploration and ceRNA networks shed light on the underlying disease mechanisms, while molecular docking proposed luteolin, isoflavone, and thalidomide as promising therapeutic contenders (70) (Table 3)

Mitochondrial dysfunction in Kupffer cells plays a central role: IR causes Kupffer cell mitochondria to release mtDNA and ROS, activating NLRP3 inflammasomes which then release IL-1 that amplifies neutrophil recruitment (67)