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457 Similarly, the CPGMB nanoplatform, composed of polydopamine-coated CeO 2 -x nanorods co-loaded with MET and GOx, inhibits glycolysis via HK2 inhibition and glucose depletion

found that Metanx TM reduced non-proliferative DR (NPDR), particularly foveal edema, retinal thickness, and improved the mean threshold retinal sensitivity [146]

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In such cases, up-regulation of the plasma membrane redox system may help maintain an adequate pool of NAD+ to fuel the increased glycolysis needed to maintain cell viability in the absence of mitochondrial activity