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Nevertheless, cannabis is usually self-administered for its mood-altering properties, and has been described as an addictive, dependence-producing drug due to the production of euphoria, the presence of reversible psychological impairment, an abstinence syndrome, and tolerance

55 When GF and conventional rodents were injected with labelled 2,4,5-trichlorobiphenyl, the level of radioactivity was 15 times higher in the adipose tissue, 48 lung, kidney and liver 56 of conventional animals, due to the accumulation of MeSO 2 -triCB

In addition, glutamate signal transduction in neurons is augmented by dopamine, therefore, nigral neurons, i.e., substantia nigra pars compacta neurons, are highly susceptible to glutamate excitotoxicity effects (85)

Moreover, it has been shown to potentiate rifampins activity in a murine tuberculosis model [94]

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