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First, osteoarthritis is one of the most common chronic pain conditions globally and is directly worsened by excess body weight

Look for "L-Glutathione" or "Reduced Glutathione," which is the active form the body uses

This interaction site is less defined but comprises the glutathione moiety of Grx(SSG), parts of helix 3, and a conserved lysine/arginine residue that also contributes to the scaffold site 14,15

By utilizing a fluorescent-tagged LC3B expression system, we demonstrated that SLC13A3 knockdown markedly promoted autophagic flux (Fig