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But production declines with age, stress, illness, toxin exposure, and poor nutrition

Ben-Sasson et al

Many on the market use synthetic versions, fillers, harmful preservatives, or low-potency formulas that fail to deliver visible improvements

When autophagy is impaired, increased p62 competes with the DLG motif for binding to the Keap1 DC pocket and inhibits the ubiquitination of Nrf2, causing Nrf2 stabilization and the increased expression of cytoprotective genes