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In a clinical setting, participants using oral glutathione supplements showed a significant reduction in melanin levels compared to placebo groups

In a randomized, placebo-controlled phase 1 clinical trial, 14-day treatment with TLC-2716 was well tolerated (primary endpoints) and resulted in placebo-adjusted reductions up to 38.5% in plasma TG and 61% in postprandial remnant cholesterol (secondary endpoints)

Doseresponse analysis further indicated a statistically significant augmentation in mortality risk at doses above 150 IU/day (27)

Adjuvant treatment of atopic eczema: Assessment of an emollient containing N-palmitoylethanolamine (ATOPA study) J