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cerevisiae , -glutamyl kinase-linker-glutathione synthetase hybrid (Pro1-GshB) from S

Moreover, metabolic heterogeneity extends its influence through paracrine effects mediated by metabolic by-products, profoundly shaping the tumor immune microenvironment [125]

100 Despite the promising effect of CQ, 100 a recent phase I/II clinical trial combining HCQ with TMZ and radiation therapy, in patients with newly diagnosed GBM showed that the maximum tolerated dose of HCQ was unable to consistently inhibit autophagy and that dose-limiting toxicity prevented the possibility of moving to higher doses of HCQ

Felber J-P, Reddy WJ, Selenkow HA, Thorn GW

Nonetheless, the mechanism behind this is still unknown