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4) Underexplored therapeutic strategies and model limitations: Preclinical studies have relied on in vitro mesangial cell models and lack validated animal models that fully recapitulate human IgA nephropathys pathological features (e.g., glomerular IgA1 deposition and mesangial proliferation)

The food intake after PBS injection was compared with the food intake after leptin administration

Current imaging approaches predominantly detect general microglial activation, without resolving the functional diversity that underpins their dualistic roles

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For instance, inhibitors of IDO1 could potentially reduce inflammation