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Additionally, the release pattern conformed to the Higuchi model as shown in Table 6 and Figure (Supplementary File) ( 3.7 Stability study The stability of the optimized quercetin-loaded niosomal formulation was meticulously evaluated over a 3-month period to assess its robustness and shelf-life under standard storage conditions

The formulation was stored at room temperature (25C 2C) and monitored at regular intervals to determine any variations in key characteristics, namely particle size, entrapment efficiency, and polydispersity index (PDI) as shown in Table 7

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doi: 10.1128/IAI.72.2.1155-1158.2004 18 HoelzerK.MorenoS

607 The iron uptake inhibitor ferristatin II provides neuroprotection by suppressing ferroptosis, and HBED treatment alleviates secondary damage after TBI by binding to Fe 2+ and converting Fe 2+ to Fe 3+