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Artif Cells Blood Substit Immobil Biotechnol

Journal of Psychoactive Drugs, 34(3), 273283

Three reasons opioid use depletes NAD: Oxidative stress Mitochondrial dysfunction Increased enzyme activity (PARPs, CD38) Regular opioid use has been linked with oxidative stress (an imbalance of free radicals and antioxidants) and mitochondrial dysfunction (problems with the cells power plants that help produce energy)