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R The multicenter NABUREN dose-finding phase 2 RCT (166 prostate cancer patients, four arms: sodium butyrate 1g, 2g, 4g daily or placebo during and 2 weeks after radiotherapy) found no evidence of efficacy for preventing acute radiation proctitis at any butyrate dose, contrasting with positive results from SCFA mixture studies in established chronic radiation proctitis

Also, everyones digestive system works a bit differently

TJs have the so-called gate and fence function as they regulate the size and charge selectivity of the paracellular pathway

Initial doses of 125-250 mcg daily allow assessment of individual response and tolerance