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Often touted for its ability to promote hair growth, support healthy skin and strengthen brittle nails, biotin also plays a crucial role in energy metabolism by helping convert carbohydrates, fats, and proteins into usable energy

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Of note, on contrast to enzymes, enantioselective introduction of a proton to transient enediol intermediate via synthetic route might be extremely challenging to control it in terms of enantioselectivity due to the small size of the proton 3,7,8,9,10,11

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Tian Q, Jiang J, Yin H, Zhang Y, Li Y, Wu P, et al

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