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Approximately 95% of CRCs are microsatellite stable, characterized by cold immune microenvironments lacking cytotoxic T-cell infiltration

doi: 10.1038/s41467-021-22885-8 163 Di IanniNMusioSPellegattaS

Considering it has been shown by studies that vitamin C is essential to human immunity, dietary or pharmaceutical supplementation would inherently reduce the risk of infection while restoring and maintaining overall immune function in these deficient subjects [50]

For example, the largely sensible advice of Mark Manson, packaged in his huge bestseller The Subtle Art of Not Giving a F*ck, advocates optimising yourself by trying less hard but with impeccable bro-y instincts opens with an admiring story about the writer Charles Bukowski

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