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Furthermore, evidence shows that most (up to 95%) pharmaceutical drugs found effective and safe in animal studies fail in subsequent clinical phases in human populations, mainly due to insufficient efficacy, toxicity, and the emergence of unacceptable adverse drug reactions, raising significant concerns for ethical and economic reasons (204211)

Neither is universally better

TUE expands the traditional PUE concept by including all power consumed inside IT equipment, such as server fans and internal power distribution losses, along with infrastructure overhead

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